Preprints





2017


Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. EMBO J 2017 Jun 27; [Epub ahead of print]
Rollins MF, Chowdhury S, Carter J, Golden SM, Wilkinson RA, Bondy-Denomy J, Lander GC, Wiedenheft B. Cas1 and the Csy complex are opposing regulators of Cas2/3 nucleaseactivity. Proc Natl Acad Sci U S A 2017 Jun 27; 114(26): E5113-E5121.
Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B. Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Cell 2017 Mar 23; 169(1): 47-57.e11.



2016


Smirnova IA, Sjostrand D, Li F, Bjorck M, Schafer J, Ostbye H, Hogbom M, von Ballmoos C, Lander GC, Adelroth P, Brzezinski P. Isolation of yeast complex IV in native lipid nanodiscs. Biochim Biophys Acta 2016 Dec; 1858(12): 2984-2992.
Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature 2016 Jun 22; 535(7611): 252-7.
Zubcevic L, Herzik MA Jr, Chung BC, Liu Z, Lander GC, Lee SY. Cryo-electron microscopy structure of the TRPV2 ion channel. Nat Struct Mol Biol 2016 Feb; 23(2): 180-6.
Dambacher CM, Worden EJ, Herzik MA, Martin A, Lander GC. Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition. Elife 2016; 5.



2015


Yang TC, Ortiz D, Nosaka L, Lander GC, Catalano CE. Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex. Biophys J 2015 Oct 20; 109(8): 1663-75.
Ciferri C, Lander GC, Nogales E. Protein domain mapping by internal labeling and single particle electron microscopy. J Struct Biol 2015 Nov; 192(2): 159-62.
Dambacher CM, Lander GC. Site-specific labeling of proteins for electron microscopy. J Struct Biol 2015 Nov; 192(2): 151-8.
Bashore C, Dambacher CM, Goodall EA, Matyskiela ME, Lander GC, Martin A. Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome. Nat Struct Mol Biol 2015 Sep; 22(9): 712-9.
McNulty R, Lokareddy RK, Roy A, Yang Y, Lander GC, Heck AJ, Johnson JE, Cingolani G. Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22. J Mol Biol 2015 Oct 9; 427(20): 3285-99.
Garnham CP, Vemu A, Wilson-Kubalek EM, Yu I, Szyk A, Lander GC, Milligan RA, Roll-Mecak A. Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. Cell 2015 May 21; 161(5): 1112-23.
Chowdhury S, Ketcham SA, Schroer TA, Lander GC. Structural organization of the dynein-dynactin complex bound to microtubules. Nat Struct Mol Biol 2015 Apr; 22(4): 345-7.
Gardner BM, Chowdhury S, Lander GC, Martin A. The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits. J Mol Biol 2015 Mar 27; 427(6 Pt B): 1375-88.



2014


Liu T, Sae-Ueng U, Li D, Lander GC, Zuo X, Jonsson B, Rau D, Shefer I, Evilevitch A. Solid-to-fluid-like DNA transition in viruses facilitates infection. Proc Natl Acad Sci U S A 2014 Oct 14; 111(41): 14675-80.
Alushin GM*, Lander GC*, Kellogg EH*, Zhang R, Baker D, Nogales E. High-resolution microtubule structures reveal the structural transitions in alphabeta-tubulin upon GTP hydrolysis. Cell 2014 May 22; 157(5): 1117-29.
*Co-first Authors
Zhao Q, Potter CS, Carragher B, Lander G, Sworen J, Towne V, Abraham D, Duncan P, Washabaugh MW, Sitrin RD. Characterization of virus-like particles in GARDASIL(R) by cryo transmission electron microscopy. Hum Vaccin Immunother 2014; 10(3): 734-9.



2013


Matyskiela ME, Lander GC*, Martin A*. Conformational switching of the 26S proteasome enables substrate degradation. Nat Struct Mol Biol 2013 Jul; 20(7): 781-8.
*Co-corresponding Authors
Lander GC, Johnson JE, Rau DC, Potter CS, Carragher B, Evilevitch A. DNA bending-induced phase transition of encapsidated genome in phage lambda Nucleic Acids Res 2013 Apr 1; 41(8): 4518-4524.
Lander GC, Martin A, Nogales E. The proteasome under the microscope: the regulatory particle in focus. Curr Opin Struct Biol 2013 Apr; 23(2): 243-51.



2012


Ciferri C, Lander GC, Maiolica A, Herzog F, Aebersold R, Nogales E. Molecular architecture of human polycomb repressive complex 2. Elife 2012; 1: e00005.
Lander GC, Saibil HR, Nogales E. Go hybrid: EM, crystallography, and beyond. Curr Opin Struct Biol 2012 Oct; 22(5): 627-35.
Roy A, Bhardwaj A, Datta P, Lander GC, Cingolani G. Small terminase couples viral DNA binding to genome-packaging ATPase activity. Structure 2012 Aug 8; 20(8): 1403-13.
Lander GC, Baudoux AC, Azam F, Potter CS, Carragher B, Johnson JE. Capsomer Dynamics and Stabilization in the T = 12 Marine Bacteriophage SIO-2 and Its Procapsid Studied by CryoEM. Structure 2012 Mar 7; 20(3): 498-503.
Lander GC*, Estrin E*, Matyskiela ME*, Bashore C, Nogales E, Martin A. Complete subunit architecture of the proteasome regulatory particle. Nature 2012 Feb 9; 482(7384): 186-91.
*Co-first Authors
Baudoux AC, Hendrix RW, Lander GC, Bailly X, Podell S, Paillard C, Johnson JE, Potter CS, Carragher B, Azam F. Genomic and functional analysis of Vibrio phage SIO-2 reveals novel insights into ecology and evolution of marine siphoviruses. Environ Microbiol 2012 Aug; 14(8): 2071-86.



2011


Wiedenheft B*, Lander GC*, Zhou K, Jore MM, Brouns SJ, van der Oost J, Doudna JA, Nogales E. Structures of the RNA-guided surveillance complex from a bacterial immune system. Nature 2011; 477(7365): 486-9.
*Co-first Authors
Tang J, Lander GC, Olia AS, Li R, Casjens S, Prevelige P Jr, Cingolani G, Baker TS, Johnson JE. Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22. Structure 2011 Apr 13; 19(4): 496-502.
Hornung P, Maier M, Alushin GM, Lander GC, Nogales E, Westermann S. Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex. J Mol Biol 2011 Jan 14; 405(2): 548-59.



2010


Huo Y, Hu Z, Zhang K, Wang L, Zhai Y, Zhou Q, Lander G, Zhu J, He Y, Pang X, Xu W, Bartlam M, Dong Z, Sun F. Crystal structure of group II chaperonin in the open state. Structure 2010 Oct 13; 18(10): 1270-9.
Matsui T, Lander GC, Khayat R, Johnson JE. Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus. Proc Natl Acad Sci U S A 2010 Aug 10; 107(32): 14111-5.
Khayat R, Lander GC, Johnson JE. An automated procedure for detecting protein folds from sub-nanometer resolution electron density. J Struct Biol 2010 Jun; 170(3): 513-21.
Voss NR, Lyumkis D, Cheng A, Lau PW, Mulder A, Lander GC, Brignole EJ, Fellmann D, Irving C, Jacovetty EL, Leung A, Pulokas J, Quispe JD, Winkler H, Yoshioka C, Carragher B, Potter CS. A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy. J Struct Biol 2010 Mar; 169(3): 389-98.



2009


Lander GC, Khayat R, Li R, Prevelige PE, Potter CS, Carragher B, Johnson JE. The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit. Structure 2009 Jun 10; 17(6): 789-99.
Ambrose RL, Lander GC, Maaty WS, Bothner B, Johnson JE, Johnson KN. Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase. J Gen Virol 2009 Sep; 90(Pt 9): 2191-200.
Lander GC, Stagg SM, Voss NR, Cheng A, Fellmann D, Pulokas J, Yoshioka C, Irving C, Mulder A, Lau PW, Lyumkis D, Potter CS, Carragher B. Appion: an integrated, database-driven pipeline to facilitate EM image processing. J Struct Biol 2009 Apr; 166(1): 95-102.



2008


Lander GC, Evilevitch A, Jeembaeva M, Potter CS, Carragher B, Johnson JE. Bacteriophage lambda stabilization by auxiliary protein gpD: timing, location, and mechanism of attachment determined by cryo-EM. Structure 2008 Sep 10; 16(9): 1399-406.
Nemecek D, Lander GC, Johnson JE, Casjens SR, Thomas GJ Jr. Assembly architecture and DNA binding of the bacteriophage P22 terminase small subunit. J Mol Biol 2008 Nov 14; 383(3): 494-501.
Stagg SM, Lander GC, Quispe J, Voss NR, Cheng A, Bradlow H, Bradlow S, Carragher B, Potter CS. A test-bed for optimizing high-resolution single particle reconstructions. J Struct Biol 2008 Jul; 163(1): 29-39.
Prasuhn DE Jr, Kuzelka J, Strable E, Udit AK, Cho SH, Lander GC, Quispe JD, Diers JR, Bocian DF, Potter C, Carragher B, Finn MG. Polyvalent display of heme on hepatitis B virus capsid protein through coordination to hexahistidine tags. Chem Biol 2008 May; 15(5): 513-9.
Strable E, Prasuhn DE Jr, Udit AK, Brown S, Link AJ, Ngo JT, Lander G, Quispe J, Potter CS, Carragher B, Tirrell DA, Finn MG. Unnatural amino acid incorporation into virus-like particles. Bioconjug Chem 2008 Apr; 19(4): 866-75.



2006


Gan L, Speir JA, Conway JF, Lander G, Cheng N, Firek BA, Hendrix RW, Duda RL, Liljas L, Johnson JE. Capsid conformational sampling in HK97 maturation visualized by X-ray crystallography and cryo-EM. Structure 2006 Nov; 14(11): 1655-65.



2007


Poliakov A, van Duijn E, Lander G, Fu CY, Johnson JE, Prevelige PE Jr, Heck AJ. Macromolecular mass spectrometry and electron microscopy as complementary tools for investigation of the heterogeneity of bacteriophage portal assemblies. J Struct Biol 2007 Feb; 157(2): 371-83.



2006


Stagg SM, Lander GC, Pulokas J, Fellmann D, Cheng A, Quispe JD, Mallick SP, Avila RM, Carragher B, Potter CS. Automated cryoEM data acquisition and analysis of 284742 particles of GroEL. J Struct Biol 2006 Sep; 155(3): 470-81.
Lander GC, Tang L, Casjens SR, Gilcrease EB, Prevelige P, Poliakov A, Potter CS, Carragher B, Johnson JE. The structure of an infectious P22 virion shows the signal for headful DNA packaging. Science 2006 Jun 23; 312(5781): 1791-5.
Shepherd CM, Borelli IA, Lander G, Natarajan P, Siddavanahalli V, Bajaj C, Johnson JE, Brooks CL 3rd, Reddy VS. VIPERdb: a relational database for structural virology. Nucleic Acids Res 2006 Jan 1; 34(Database issue): D386-9.



2005


Natarajan P, Lander GC, Shepherd CM, Reddy VS, Brooks CL 3rd, Johnson JE. Exploring icosahedral virus structures with VIPER. Nat Rev Microbiol 2005 Oct; 3(10): 809-17.



2004


Reddy V, Natarajan P, Lander G, Qu C, Brooks III C, Johnson JE. Virus Particle Explorer (Viper): A repository of Virus Capsid Structures Conformational Proteomics of Macromolecular Structure 2004; RH Cheng andL Hammer, World Scientific Pub Co., Singapore, 403-412 (Book Chapter)
Berardini TZ, Mundodi S, Reiser L, Huala E, Garcia-Hernandez M, Zhang P, Mueller LA, Yoon J, Doyle A, Lander G, Moseyko N, Yoo D, Xu I, Zoeckler B, Montoya M, Miller N, Weems D, Rhee SY. Functional annotation of the Arabidopsis genome using controlled vocabularies. Plant Physiol 2004 Jun; 135(2): 745-55.



2003


Rhee SY, Beavis W, Berardini TZ, Chen G, Dixon D, Doyle A, Garcia-Hernandez M, Huala E, Lander G, Montoya M, Miller N, Mueller LA, Mundodi S, Reiser L, Tacklind J, Weems DC, Wu Y, Xu I, Yoo D, Yoon J, Zhang P. The Arabidopsis Information Resource (TAIR): a model organism database providing a centralized, curated gateway to Arabidopsis biology, research materials and community. Nucleic Acids Res 2003 Jan 1; 31(1): 224-8.