Preprints of submitted manuscripts


Bruggemann J, Lander GC, Su AI. Exploring Applications of Crowdsourcing to Cryo-EM. bioRxiv 2017 November 15
Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer T, Lander G. Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility. bioRxiv 2017 August 31
Chowdhury S, Otomo C, Leitner A, Ohashi K, Aebersold R, Lander GC, Otomo T. Structural analyses reveal that the ATG2A-WIPI4 complex functions as a membrane tether for autophagosome biogenesis. bioRxiv 2017 August 24
Herzik MA, Fraser J, Lander GC. A multi-model approach to assessing local and global cryo-EM map quality. bioRxiv 2017 April 19



Peer-reviewed publications


Journal names have been removed from the list below.
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2017


Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY. Structure of the cold- and menthol-sensing ion channel TRPM8. 2017 Dec 7
Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC. Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. 2017 Nov 3

Associated preprint (submitted 2017 September 15)
Hirschi M, Herzik MA Jr, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY. Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. 2017 Oct 19
Herzik MA Jr, Wu M, Lander GC. Achieving better-than-3-A resolution by single-particle cryo-EM at 200 keV. 2017 Nov

Associated preprint (submitted 2017 May 25)
Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer. 2017 Aug 1
Rollins MF, Chowdhury S, Carter J, Golden SM, Wilkinson RA, Bondy-Denomy J, Lander GC, Wiedenheft B. Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity. 2017 Jun 27
Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B. Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. 2017 Mar 23



2016


Smirnova IA, Sjostrand D, Li F, Bjorck M, Schafer J, Ostbye H, Hogbom M, von Ballmoos C, Lander GC, Adelroth P, Brzezinski P. Isolation of yeast complex IV in native lipid nanodiscs. 2016 Dec
Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. 2016 Jul 14
Zubcevic L, Herzik MA Jr, Chung BC, Liu Z, Lander GC, Lee SY. Cryo-electron microscopy structure of the TRPV2 ion channel. 2016 Feb
Dambacher CM, Worden EJ, Herzik MA, Martin A, Lander GC. Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition. 2016 Jan 8



2015


Yang TC, Ortiz D, Nosaka L, Lander GC, Catalano CE. Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex. 2015 Oct 20
Bashore C, Dambacher CM, Goodall EA, Matyskiela ME, Lander GC, Martin A. Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome. 2015 Sep
McNulty R, Lokareddy RK, Roy A, Yang Y, Lander G, Heck AJ, Johnson JE, Cingolani G. Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22. 2015 Oct 9
Garnham CP, Vemu A, Wilson-Kubalek EM, Yu I, Szyk A, Lander GC, Milligan RA, Roll-Mecak A. Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. 2015 May 21
Chowdhury S, Ketcham SA, Schroer TA, Lander GC. Structural organization of the dynein-dynactin complex bound to microtubules. 2015 Apr



2014


Liu T, Sae-Ueng U, Li D, Lander GC, Zuo X, Jonsson B, Rau D, Shefer I, Evilevitch A. Solid-to-fluid-like DNA transition in viruses facilitates infection. 2014 Oct 14
Zhao Q, Potter CS, Carragher B, Lander G, Sworen J, Towne V, Abraham D, Duncan P, Washabaugh MW, Sitrin RD. Characterization of virus-like particles in GARDASIL(R) by cryo transmission electron microscopy. 2014



2013


Lander GC, Johnson JE, Rau DC, Potter CS, Carragher B, Evilevitch A. DNA bending-induced phase transition of encapsidated genome in phage lambda. 2013 Apr



2012


Ciferri C, Lander GC, Maiolica A, Herzog F, Aebersold R, Nogales E. Molecular architecture of human polycomb repressive complex 2. 2012 Oct 30
Lander GC, Saibil HR, Nogales E. Go hybrid: EM, crystallography, and beyond. 2012 Oct
Roy A, Bhardwaj A, Datta P, Lander GC, Cingolani G. Small terminase couples viral DNA binding to genome-packaging ATPase activity. 2012 Aug 8
Lander GC, Baudoux AC, Azam F, Potter CS, Carragher B, Johnson JE. Capsomer dynamics and stabilization in the T = 12 marine bacteriophage SIO-2 and its procapsid studied by CryoEM. 2012 Mar 7
Lander GC, Estrin E, Matyskiela ME, Bashore C, Nogales E, Martin A. Complete subunit architecture of the proteasome regulatory particle. 2012 Jan 11
Baudoux AC, Hendrix RW, Lander GC, Bailly X, Podell S, Paillard C, Johnson JE, Potter CS, Carragher B, Azam F. Genomic and functional analysis of Vibrio phage SIO-2 reveals novel insights into ecology and evolution of marine siphoviruses. 2012 Aug



2011


Wiedenheft B, Lander GC, Zhou K, Jore MM, Brouns SJJ, van der Oost J, Doudna JA, Nogales E. Structures of the RNA-guided surveillance complex from a bacterial immune system. 2011 Sep 21
Tang J, Lander GC, Olia AS, Li R, Casjens S, Prevelige P Jr, Cingolani G, Baker TS, Johnson JE. Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22. 2011 Apr 13
Hornung P, Maier M, Alushin GM, Lander GC, Nogales E, Westermann S. Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex. 2011 Jan 14



2010


Huo Y, Hu Z, Zhang K, Wang L, Zhai Y, Zhou Q, Lander G, Zhu J, He Y, Pang X, Xu W, Bartlam M, Dong Z, Sun F. Crystal structure of group II chaperonin in the open state. 2010 Oct 13
Voss NR, Lyumkis D, Cheng A, Lau PW, Mulder A, Lander GC, Brignole EJ, Fellmann D, Irving C, Jacovetty EL, Leung A, Pulokas J, Quispe JD, Winkler H, Yoshioka C, Carragher B, Potter CS. A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy. 2010 Mar



2009


Lander GC, Khayat R, Li R, Prevelige PE, Potter CS, Carragher B, Johnson JE. The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit. 2009 Jun 10
Ambrose RL, Lander GC, Maaty WS, Bothner B, Johnson JE, Johnson KN. Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase. 2009 Sep
Lander GC, Stagg SM, Voss NR, Cheng A, Fellmann D, Pulokas J, Yoshioka C, Irving C, Mulder A, Lau PW, Lyumkis D, Potter CS, Carragher B. Appion: an integrated, database-driven pipeline to facilitate EM image processing. 2009 Apr



2008


Nemecek D, Lander GC, Johnson JE, Casjens SR, Thomas GJ Jr. Assembly architecture and DNA binding of the bacteriophage P22 terminase small subunit. 2008 Nov 14
Stagg SM, Lander GC, Quispe J, Voss NR, Cheng A, Bradlow H, Bradlow S, Carragher B, Potter CS. A test-bed for optimizing high-resolution single particle reconstructions. 2008 Jul
Prasuhn DE Jr, Kuzelka J, Strable E, Udit AK, Cho SH, Lander GC, Quispe JD, Diers JR, Bocian DF, Potter C, Carragher B, Finn MG. Polyvalent display of heme on hepatitis B virus capsid protein through coordination to hexahistidine tags. 2008 May
Strable E, Prasuhn DE Jr, Udit AK, Brown S, Link AJ, Ngo JT, Lander G, Quispe J, Potter CS, Carragher B, Tirrell DA, Finn MG. Unnatural amino acid incorporation into virus-like particles. 2008 Apr



2006


Gan L, Speir JA, Conway JF, Lander G, Cheng N, Firek BA, Hendrix RW, Duda RL, Liljas L, Johnson JE. Capsid conformational sampling in HK97 maturation visualized by X-ray crystallography and cryo-EM. 2006 Nov



2007





2006


Stagg SM, Lander GC, Pulokas J, Fellmann D, Cheng A, Quispe JD, Mallick SP, Avila RM, Carragher B, Potter CS. Automated cryoEM data acquisition and analysis of 284742 particles of GroEL. 2006 Sep
Lander GC, Tang L, Casjens SR, Gilcrease EB, Prevelige P, Poliakov A, Potter CS, Carragher B, Johnson JE. The structure of an infectious P22 virion shows the signal for headful DNA packaging. 2006 Jun 23
Shepherd CM, Borelli IA, Lander G, Natarajan P, Siddavanahalli V, Bajaj C, Johnson JE, Brooks CL 3rd, Reddy VS. VIPERdb: a relational database for structural virology. 2006 Jan 1



2005


Natarajan P, Lander GC, Shepherd CM, Reddy VS, Brooks CL 3rd, Johnson JE. Exploring icosahedral virus structures with VIPER. 2005 Oct



2004


Berardini TZ, Mundodi S, Reiser L, Huala E, Garcia-Hernandez M, Zhang P, Mueller LA, Yoon J, Doyle A, Lander G, Moseyko N, Yoo D, Xu I, Zoeckler B, Montoya M, Miller N, Weems D, Rhee SY. Functional annotation of the Arabidopsis genome using controlled vocabularies. 2004 Jun



2003


Rhee SY, Beavis W, Berardini TZ, Chen G, Dixon D, Doyle A, Garcia-Hernandez M, Huala E, Lander G, Montoya M, Miller N, Mueller LA, Mundodi S, Reiser L, Tacklind J, Weems DC, Wu Y, Xu I, Yoo D, Yoon J, Zhang P. The Arabidopsis Information Resource (TAIR): a model organism database providing a centralized, curated gateway to Arabidopsis biology, research materials and community. 2003 Jan 1