Preprints of submitted manuscripts
Structural basis for piRNA-targeting
Anzelon TA, Chowdhury S, Hughes SM, Xiao Y, Lander GC, MacRae IJ
Online December 7, 2020
Online December 7, 2020
bioRxiv DOI: 10.1101/2020.12.07.413112
Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation
Shin M, Watson ER, Novick SJ, Griffin PR, Wiseman L, Lander GC
Online November 23, 2020
Online November 23, 2020
bioRxiv DOI: 10.1101/2020.11.23.394858
A guided approach for subtomogram averaging of challenging macromolecular assemblies
Grotjahn D, Chowdhury S, Lander GC
Online February 02, 2020
Online February 02, 2020
bioRxiv DOI: 10.1101/2020.02.01.930297
Peer-reviewed publications
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2020
Sub-2 Angstrom resolution structure determination using single-particle cryo-EM at 200keV.
Wu M, Lander GC, Herzik MA Jr
Published 2020
Published 2020
Associated preprint (posted November 26, 2019)
Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.
Shin M, Puchades C, Asmita A, Puri N, Adjei E, Wiseman RL, Karzai AW, Lander GC
Published May 2020
Published May 2020
Associated preprint (posted April 24, 2019)
Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing.
Fribourgh JL, Srivastava A, Sandate CR, Michael AK, Hsu PL, Rakers C, Nguyen LT, Torgrimson MR, Parico GCG, Tripathi S, Zheng N, Lander GC, Hirota T, Tama F, Partch CL
Published Feb 26, 2020
Published Feb 26, 2020
Associated preprint (posted August 20, 2019)
Associated Depositions:
6OF7
6OF7
2019
Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation.
Greene ER, Goodall EA, de la Pena AH, Matyskiela ME, Lander GC, Martin A
Published Nov 28, 2019
Published Nov 28, 2019
Associated preprint (posted July 2, 2019)
Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY
Published Aug 20, 2019
Published Aug 20, 2019
Associated preprint (posted January 9, 2019)
Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.
Puchades C, Ding B, Song A, Wiseman RL, Lander GC, Glynn SE
Published Sep 5, 2019
Published Sep 5, 2019
Associated preprint (posted February 15, 2019)
Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry.
Rollins MF, Chowdhury S, Carter J, Golden SM, Miettinen HM, Santiago-Frangos A, Faith D, Lawrence CM, Lander GC, Wiedenheft B
Published Apr 4, 2019
Published Apr 4, 2019
Associated preprint (posted October 26, 2018)
High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM.
Herzik MA Jr, Wu M, Lander GC
Published Mar 4, 2019
Published Mar 4, 2019
Associated preprint (posted December 7, 2018)
Associated Depositions:
EMD-0406 | 6NBB | EMPIAR-10249
EMD-0407 | 6NBC | EMPIAR-10250
EMD-0408 | 6NBD | EMPIAR-10250
EMD-0409 | EMPIAR-10252
EMD-0406 | 6NBB | EMPIAR-10249
EMD-0407 | 6NBC | EMPIAR-10250
EMD-0408 | 6NBD | EMPIAR-10250
EMD-0409 | EMPIAR-10252
A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality.
Herzik MA Jr, Fraser JS, Lander GC
Published Feb 5, 2019
Published Feb 5, 2019
Associated preprint (posted April 19, 2017)
2018
Conformational ensemble of the human TRPV3 ion channel.
Zubcevic L, Herzik MA Jr, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY
Published Nov 14, 2018
Published Nov 14, 2018
Associated preprint (posted August 20, 2018)
Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
de la Pena AH, Goodall EA, Gates SN, Lander GC, Martin A
Published Nov 30, 2018
Published Nov 30, 2018
Associated preprint (posted August 16, 2018)
Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex.
Chowdhury S, Otomo C, Leitner A, Ohashi K, Aebersold R, Lander GC, Otomo T
Published Oct 16, 2018
Published Oct 16, 2018
Associated preprint (posted August 24, 2017)
Exploring applications of crowdsourcing to cryo-EM.
Bruggemann J, Lander GC, Su AI
Published Jul 2018
Published Jul 2018
Associated preprint (posted November 15, 2017)
Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility.
Grotjahn DA, Chowdhury S, Xu Y, McKenney RJ, Schroer TA, Lander GC
Published Mar 2018
Published Mar 2018
Associated preprint (posted August 31, 2017)
2017
Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.
Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC
Published Nov 3, 2017
Published Nov 3, 2017
Associated preprint (posted September 15, 2017)
Achieving better-than-3-A resolution by single-particle cryo-EM at 200 keV.
Herzik MA Jr, Wu M, Lander GC
Published Nov 2017
Published Nov 2017
Associated preprint (posted May 25, 2017)
Associated Depositions:
EMD-8741 | 5VY3 | EMPIAR-10185
EMD-8742 | 5VY4 | EMPIAR-10186
EMD-8743 | 5VY5 | EMPIAR-10181
EMD-8741 | 5VY3 | EMPIAR-10185
EMD-8742 | 5VY4 | EMPIAR-10186
EMD-8743 | 5VY5 | EMPIAR-10181
Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.
Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B
Published Mar 23, 2017
Published Mar 23, 2017
2016
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP
Published Jul 14, 2016
Published Jul 14, 2016
Associated Depositions:
5HXB
5HXB
2015
2014
High-resolution microtubule structures reveal the structural transitions in alphabeta-tubulin upon GTP hydrolysis.
Alushin GM, Lander GC, Kellogg EH, Zhang R, Baker D, Nogales E
Published May 22, 2014
Published May 22, 2014
Characterization of virus-like particles in GARDASIL(R) by cryo transmission electron microscopy.
Zhao Q, Potter CS, Carragher B, Lander G, Sworen J, Towne V, Abraham D, Duncan P, Washabaugh MW, Sitrin RD
Published 2014
Published 2014
2013
2012
Genomic and functional analysis of Vibrio phage SIO-2 reveals novel insights into ecology and evolution of marine siphoviruses.
Baudoux AC, Hendrix RW, Lander GC, Bailly X, Podell S, Paillard C, Johnson JE, Potter CS, Carragher B, Azam F
Published Aug 2012
Published Aug 2012
2011
2010
A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy.
Voss NR, Lyumkis D, Cheng A, Lau PW, Mulder A, Lander GC, Brignole EJ, Fellmann D, Irving C, Jacovetty EL, Leung A, Pulokas J, Quispe JD, Winkler H, Yoshioka C, Carragher B, Potter CS
Published Mar 2010
Published Mar 2010
2009
Ab initio maximum likelihood reconstruction from cryo electron microscopy images of an infectious virion of the tailed bacteriophage P22 and maximum likelihood
versions of Fourier Shell Correlation appropriate for measuring resolution of
spherical or cylindrical objects.
Prust CJ, Doerschuk PC, Lander GC, Johnson JE
Published Sep 2009
Published Sep 2009
2008
Bacteriophage lambda stabilization by auxiliary protein gpD: timing, location, and mechanism of attachment determined by cryo-EM.
Lander GC, Evilevitch A, Jeembaeva M, Potter CS, Carragher B, Johnson JE
Published Sep 10, 2008
Published Sep 10, 2008
2006
2007
2006
2005
2004
Functional annotation of the Arabidopsis genome using controlled vocabularies.
Berardini TZ, Mundodi S, Reiser L, Huala E, Garcia-Hernandez M, Zhang P, Mueller LA, Yoon J, Doyle A, Lander G, Moseyko N, Yoo D, Xu I, Zoeckler B, Montoya M, Miller N, Weems D, Rhee SY
Published Jun 2004
Published Jun 2004
2003
The Arabidopsis Information Resource (TAIR): a model organism database providing a centralized, curated gateway to Arabidopsis biology, research materials and
community.
Rhee SY, Beavis W, Berardini TZ, Chen G, Dixon D, Doyle A, Garcia-Hernandez M, Huala E, Lander G, Montoya M, Miller N, Mueller LA, Mundodi S, Reiser L, Tacklind J, Weems DC, Wu Y, Xu I, Yoo D, Yoon J, Zhang P
Published Jan 1, 2003
Published Jan 1, 2003